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Cushings in Dogs: Treatment Options Overview

There are numerous treatment options to consider for dogs that have been diagnosed with Cushings disease, also known as canine cushings disease and hyperadrenocorticism. These options are conventional medicinal treatments, natural and herbal treatments, and/or surgery (but only in extremely rare cases). Due to the fact that Cushings in dogs can be difficult to diagnose, oftentimes a natural treatment is recommended by veterinarians. Natural, holistic treatment options for Cushings in dogs are gentle on aging dogs and can be used if Cushing’s is only suspected. Natural treatment options are also less expensive and they have a high success rate. Exploring homeopathic options for Cushing’s in dogs is usually the first route as these options possess the added benefit of little to no side effects.


Natural treatments: Natural remedies for Cushings in dogs/natural treatment options include melatonin, lignans, milk thistle, and SAMe. These dietary supplements have little to no side effects and are often used as a first treatment option for Cushing’s disease. Cortisol, the stress hormone, is produced in excess in Cushingoid dogs, which is the cause of most of the symptoms. Controlling the amount of cortisol means controlling the symptoms. Flaxseed lignans and melatonin both inhibit different enzymes needed in the production of cortisol. In restoring hormone levels back to normal, flaxseed lignans and melatonin can help manage the symptoms. Studies have found that the combination of lignans and melatonin not only reduce cortisol, but act directly upon adrenal tumor cells, effectively treating both typical and atypical cushings disease. Milk thistle and SAMe are dietary supplements that help support the liver. Liver support is beneficial for dogs with Cushing’s because the disease puts a great deal of stress on the liver, causing it to become overworked.

Click here to read testimonials on natural Cushing’s treatment options. You can read about real life experiences treating Canine Cushings Disease with lignans, melatonin, and more.

Conventional treatments: These include Lysodren, Ketoconozole, and Trilostane. Although they can be effective, it is important to remember that they are chemotherapy drugs. They can be expensive and much care is needed in monitoring the results. These drugs are used to deliberately damage the outer adrenal cortex to reduce cortisol production. If the dosage is too high or if the medication is administered for an extended period of time, the adrenal gland can be damaged to the point where it stops producing cortisol all together. This causes Addison’s disease, the opposite of Cushing’s disease, and monthly monitoring and steroid injections would be needed to make up for the cortisol deficit if this occurs. To ensure these chemotherapy drugs only reduce cortisol rather than eliminating it, and to confirm that they do not cause excessive damage to the adrenal gland, frequent monitoring and testing is required.
Surgery: Cushings in dogs is caused by either a tumor in the adrenal gland or a tumor in the pituitary gland. Because of the pituitary gland’s location, the removal of the tumor would require brain surgery, which is not performed on dogs. This procedure would be extremely risky and the cost would be astronomical. While surgery on the pituitary gland is not done, adrenal gland tumor surgery can be performed; however, it is rare because of the aforementioned risk and cost.

44 Responses so far.

  1. christina owens says:

    I’m using Trilostane for 2 mo. for my Yorkie. She’s already lost 2 #. One more month of this and then switching to natural supplements recommended here. Do you need to give this trmt. for the life of the dog? Where’s the place to get these supplements?
    Thankyou for your help!

    • Cushings in Dogs says:

      When a dog has Cushing’s, treatment is recommended for the rest of the dog’s life in order to manage the symptoms. Unfortunately there is no cure for the disease – aside from extremely expensive and risky surgeries, which are very rarely suggested. This is another reason natural treatment options are often considered: they are inexpensive and more gentle than conventional medications, therefore using them for an extended period is more manageable. We highly encourage you to consult your vet about switching (if you haven’t already) as they are more familiar with your dog’s particular case since each one is different. As far as a good source for lignans and melatonin, we recommend http://www.lignans.net/ They provide quality products and valuable information.

      • Ann London says:

        My doxie is 12 and she’s doing ok on Vetoryl. She can’t seem to settle down into a comfy position for a nap or just to sit, day or night. Is this a Cushings symptom? Any suggestions?

        • Cushings in Dogs says:

          Restlessness and pacing can be a Cushing’s symptom due to the excess Cortisol (the stress hormone). Supplements like melatonin can help; however, we recommend discussing this with your veterinarian if the Vetoryl hasn’t been able to address this symptom.

    • Molly says:

      On Amazon is where I get them. All delivered to you without you having to go find them. Lignans for life, petalive Cushex drops. Youcan also get sam-e there as well as melatonin

  2. Eva says:

    How much melotin or milk thistle do you give a 100 lbs dog

    • Cushings in Dogs says:

      As per the College of Veterinary Medicine at the University of Tennessee, who developed the protocol for treating Cushings with lignans and melatonin, recommended dosage for melatonin is 3 mg every 12 hours for dogs under 30 lbs and 6 mg every 12 hours for dogs over 30 lbs. Based on this suggestion, your dog would take 6 mg every 12 hours to keep the melatonin at a constant level in the body. We suggest consulting your vet to make sure this falls in line with their recommended treatment practice.
      Recommended dosage for Milk Thistle is approximately 2 mg per pound of body weight, so your dog could potentially have up to 200 mg of milk thistle; however, as stated above, we always encourage readers to consult their veterinarian when introducing any new supplement to their dog’s diet.

  3. Jacqueline Ginetz says:

    Can you apply the same holistic treatments to either adrenal or pituitary cushings disease?

    • Cushings in Dogs says:

      Holistic treatments can be used for either; however, every Cushings case is different. We always recommend consulting your vet as they are most familiar with the severity of your dog’s particular case.

  4. Larry says:

    I just lost my Border Terrier to Cushings. We tried traditional as well as Holistic Medicine, but in the end I couldn’t help her.
    I wish I had found this website sooner.

    • Cushings in Dogs says:

      We are sorry to hear about your dog. There are far too many Cushings cases each year and we hope to continue raising awareness of the disease.

  5. Norma says:

    My dog is on medication for Cushings. He still does a lot heavy panting. Will that ever subside?

    • Cushings in Dogs says:

      When a dog has Cushing’s, they will have it for life. Even if they are on medication, the tumor will still remain, therefore the symptoms can linger. It is tough to say if the panting will subside since we are not familiar with your dog’s particular case and every dog is different, so you’ll have to consult your vet. But we can tell you that regardless of whether you are using conventional or holistic treatments, the goal remains the same: to reduce excess Cortisol, thus managing the symptoms. If you are using conventional medicine, oftentimes people will use holistic treatments at the same time to help manage the symptoms. If you do not feel that your current medication is helping enough, it might be time to talk to your vet about trying something different or introducing some natural supplements to see if they can help manage some or all of the symptoms. Best of luck!

  6. Carol says:

    My dog uses Vetryol from vet. 1 and half years ago i found a chriopractor that does frequency specific microcurrent(fsm) . He has shown great improvement and vet says he is symptom free. He gets raw diet and some nutrional supplements

    • Cushings in Dogs says:

      Thank you for your comment, Carol! What supplements do you give your dog?

    • Hi Carol….what breed is your dog…wondering if small breed? Our yorkie is in need of help asap….vet suggesting Vetryol. Trying to decide whether to use this or homeopathic remedies. How long as your dog been on Vetryol?

  7. Web Hosting says:

    Surgical techniques to remove pituitary tumors in dogs are being studied, but surgery is not a widely available option.

  8. Jan says:

    I currently have my Shih-Tzu on K9 Choice Melatonin 3mg 2x daily and HMR Lignans 20mg 1x daily. If I added Milk Thistle and SAMe, what would the dosage be for a dog that weighs 14 lbs.? While I’ve seen quite a positive change in my 8 year old, such as energy, alertness, no excessive panting or snoring and weight loss, he still acts famished and downs his food in a matter of seconds. His water consumption is still somewhat more than pre-Cushings but less than it has been post-Cushings. I had started him out on Vetoryl but after just 6 months there wasn’t any notable difference had he started having negative effects so I switched him to the Melatonin and Lignans about 3 months ago. He goes in to see the vet in a week to have his Cortisol levels checked. It will be interesting to see how improved they may be. I also stopped grains and dry kibble and plan on putting him on a raw diet once we have cortisol levels checked.

    • Cushings in Dogs says:

      Hi Jan, we are glad the lignans and melatonin have been able to help manage some of the symptoms. Recommended dosage for SAMe would be about 100 mg for a dog that size, but every case is different, so we recommend checking with your vet to see if they have any specific instructions regarding liver support. Milk thistle is usually about 2 mg per lb of body weight, but again, you’ll want to consult your veterinarian to see what they think for your dog’s particular case. Good luck!

  9. Sean F Foley says:

    Is there a cause for Cushine’s and how long can a dog live with it? My dog is a 70 lb, 11 year old male lab mix.

    • Cushings in Dogs says:

      Cushings is usually caused by an adrenal or pituitary gland tumor. This results in an excess production of Cortisol, the stress hormone. The heightened Cortisol levels cause dogs to experience common Cushings symptoms like hair loss, panting, excess hunger and thirst, etc. Fortunately, oftentimes Cushings symptoms can be managed. Every dog is different, as is each Cushings case. Some people are able to find a treatment regimen to help extend their dog’s life by years, others are not as fortunate. We recommend getting multiple opinions from veterinarians to find the best recourse. In the meantime, check out our Holistic Treatment Options Page, our Medical Treatment Options Page, and our Vet Recommended Treatment Options Page. All of these links can be found at the top of this page. Good luck!

  10. Mila says:

    My dog just got diagnosed with Cushing’s a month ago. He is on milk thistle, lignans and melatonin with other herbal supplements. However, I got really worried with his liver enzymes, They’re so high. And the pot belly seems disturbing too. Please help recommend other ways to protect the liver. He’s also on a grain-free diet already.

    • Cushings in Dogs says:

      We’re sorry to hear about your dog. Since you are going the natural route, another supplement that’s worth looking into and worth discussing with your vet is SAMe. This, in conjunction with milk thistle, can help support the liver and may be able to help lower those enzymes. Also keep in mind that it can take up to a few months to see results with some medications and supplements. If you don’t see improvements after a few months, it may be time to switch up the regimen, but we always recommend discussing all options with your vet as they are most familiar with your dog and each Cushings case is different. Good luck!

  11. Dianne says:

    I have a 10 1/2 year old black lab that may or may not have Cushings disease. Her most recent blood panels showed signs of elevated liver enzymes among other things. She had an abdominal ultrasound last week that showed nodules on her adrenal glands as well as a mass on her spleen. I am considering testing her for Cushings, but would not want to subject her to the more harsh conventional medicines. I would definitely try the natural holistic route. My concern is that her spleen and or liver could be compromised by cancer. They want to remove the spleen if they can control the Cushings but I won’t put her through a harsh surgery.
    She really hasn’t presented any major symptoms at this point. She has always gobbled down her food and drinks a good amount of water. Her urination habits do not seem out of the ordinary. Does it make sense to pass on the expensive testing and try and talk to the vet about holistic methods instead. I just lost our other dog last week from other issues so dealing with that grief and this now is overwhelming…

    • Cushings in Dogs says:

      We’re sorry to hear about your dog. We always recommend discussing all of your options with your veterinarian as it may be worth it to explore alternative treatment regimens, as opposed to trying anything too extreme. It may also be beneficial to talk to your vet about getting your dog on some liver supplements (i.e. SAMe and/or Milk Thistle). The natural supplements for Cushings (i.e. lignans and melatonin) can be given to your dog even if Cushing’s is only suspected because they are natural products that are gentle on aging dogs. We suggest getting your vet’s input on whether to move forward or not since they are most familiar with your dog.

  12. Jill says:

    Louie our 15 year old Staffiie has been diagnosed with Cushing’s. An ultrasound showed a large mass around the adrenal glands. We’ve started him on 60mg Vetoryl today, but I’m interested in the effects of milk thistle on tumours, especially as vet suspects there might be a pituitary tumour too. He’s 18.5 kg what sort of dosage would we be looking at and would it even be suitable/advisable to add the supplement. We’re monitoring and taking him back in 2 weeks. He’s on Royal Canin GI low fat wet and dry food and has been for the past 12 months since he was diagnosed with Pancreatitis. He takes Yumove and Yucalm, but may not need the latter if the Vetoryl treatment helps calm him. Grateful for any advice.

    • Cushings in Dogs says:

      Milk Thistle can be recommended for liver support and the usual recommendation is 1-2 mg per pound of body weight; however, your veterinarian may have different dosage recommendations since each Cushing’s case is different. Research has indicated lignans can act against tumors as well, but again, it is important to consult a holistic veterinarian with knowledge of alternative options since you are wanting to introduce natural supplements to your dog’s regimen. Here are a few links you might find helpful:

  13. Cindy says:

    my dog Rocky is our 13 year old Jack Russell/Chiwaha has been diagnosed with Cushing’s. An ultrasound showed a large mass around the pituitary glands releases ACTH hormone from the brain as the vet explained me. I am waiting for the 2nd blood test. what is the natural way to cure this disease I heard it can be very expensive plus side effects.
    Please advise me where I can get these natural remedy.

    • Cushings in Dogs says:

      While there isn’t a cure, there are ways to manage the symptoms by reducing the excess cortisol in the body. You can read about natural, alternative treatment methods on this page: Always consult your veterinarian before introducing a new regimen; we wish you luck in your research.

  14. Cushing's Chihuahua owner says:

    I wanted to leave a personal testimonial to my experience with a natural approach to Cushing’s. We adopted an extremely neglected dog that we suspect was used as a breeder in a puppy mill. She was in very poor health overall with multiple conditions, with a primary issue being Cushing’s that she probably had for some time and was not treated for (which I believe was also contributing to/exasperating her other issues). It was touch and go as to her prognosis. An ultrasound revealed she has a growth on her adrenal gland, and liver and pancreas issues (high lab values, “sludge” in the pancreas, etc.). She’s been on melatonin, lignans (both HMR and flaxseed) as well as a Chinese medicine supplement Ophiopogon from our holistic vet. She also receives SAM-E and milk thistle, along with other supplements such as enzymes to help her absorb the nutrients from her food, probiotics, fish oil, mushrooms for immunity, etc. It’s been a year and she has responded wonderfully. Her pot belly (which was very prominent) is gone, her drinking/urinating has greatly reduced, and her coat is starting to finally show signs of improvement though she still has skin issues, including warts from her impaired immune system. She is also on raw organic freeze dried food, which provides the important nutritional support. I’m a big believer in natural medicine and just so happy to see her thriving using these treatments and knowing we didn’t have to resort to the “conventional” approach which is extremely had on dogs. Thankful for holistic vets and resources like this site that allowed us to give her a good quality of life.

    • Cushings in Dogs says:

      Thank you for sharing your experience; we will add this to our testimonials page for our readers. We are so glad you found a successful regimen and that your dog is doing well!

  15. Marie says:

    I have a 5.5 lbs Maltese who is 16 yrs old. Been on Vetoryl for 3 mos. Has had 2 ACTH tests and gotten very good results. Her drinking and excess peeing has stopped. Her hair seems to be getting thicker. She is really like a younger dognow. Glad I started the meds….was really scared of them but a Facebook group really helped with information about this awful disease.

  16. Max says:

    Sorry for the incoming wall of text, please bare with me if you can: I have a 12 year old dachsund that I am suspecting Cushing’s in. Last week he began wetting the bed and drinking tons of water and acting very hungry. He is now peeing every 30 minutes to every 2 hours or so. I have gotten to the point where I set an alarm every hour overnight to take him outside. Over the past year, he also has been experiencing spikes in his liver count. We got blood and urine analysis done on Tuesday and last night the vet called and talked over the results. His liver count went over 4K where it was 600 just a month or so ago. He does pant at night, but it seems to only happen when he really needs to pee/drink water, though I worry that it will begin to happen more if it is Cushings. He is bloated and also has trouble going No. 2 it seems. The specific gravity of his pee is very low. His thyroid numbers were low too. He has a lot of protein in his urine as well.

    Today he started demoral(sp?) for his liver count, which he used to be on when we first found his liver count was high. Tomorrow we go in for an ultrasound to see what, if anything, they can find. I hear the adrenal gland tumors are less common than the pituitary is that true?

    He also mentioned the ACTH test when he went over his blood/urine numbers with me, but he said he wants to wait till after the ultrasound results and wants to consult the specialist that will be coming in to administer the ultrasound. I trust my vet very much, been bringing family pets to him over 20 years since I was a kid(this is my first pet of my own). I am happy to have found this website because a lot of literature I had been finding so far is very gloomy.

    So, my questions to you are, since we are getting the ultrasound and possibly the ACTH, what else do you recommend I ask the vet to try and determine if it truly is Cushing’s, or is what we are having done enough to make the determination? And in the time we are waiting, what else can I do to help my baby till we have an answer? Foodwise, I feed him science diet’s sensitive system mixed with a little wet food from Blue Buffalo. He gets a couple treats a day and also gets egg whites at human lunchtime most days.

    • Cushings in Dogs says:

      Yes, the majority of Cushing’s cases are pituitary and Cushings can be difficult to diagnose at times, but it does sound like your dog is experiencing a few of the symptoms associated with Cushings, so you are taking the right measures. Many vets send blood tests to the University of Tennessee because their college of veterinary medicine is an authority on Cushings and they have conducted several studies to determine the best treatment regimens for the disease. In the meantime, you can always try to alleviate the symptoms with some natural treatments because some supplements, like lignans and melatonin, can be used when Cushing’s is only suspected. They are mild yet effective in many cases. Check out our holistic treatment options page for more info: and remember to consult your vet before trying any new regimens. Wishing you lots of luck.

  17. Susan says:

    My 12 3/4 year old Shih-Tzu/Maltese Mix, Lancelot has just been dx with Adrenal Dependent Cushing’s Disease. He has a 1 1/2″ tumor on his adrenal gland. My vet said he thought the tumor was encapsulated and he did not see issues with the other organs except for some cysts on his kidneys. Lancelot does have renal dysfunction with about 30% function. My vet wants to do surgery but he did caution me about the risks. I’ve done some research and the fatality rate is pretty high during surgery and 24 hours after. As anyone been through this procedure? I want to do what’s best for Lancelot but I have some serious concerns about the surgery. Thank you.

    • Cushings in Dogs says:

      Hi Susan, surgery is very rare for dogs with Cushing’s due to the fatality rate you mentioned. Since your vet has recommended a risky procedure, we suggest seeking out a second and third opinion so you can consider all of your options. You may want to check out this list of holistic vets to see if there are any near you so you can get a variety: We wish you luck in your search.

  18. pat says:

    I live in Lexington, Ky. My Mimi., a 14 year old chow-huskie, has cushings. Can anyone suggest a vet that knows about treatments–natural, holistic, conventional. I want someone who is knowledgeable about alternatives and will work with me to give Mimi the best care possible.

    • Cushings in Dogs says:

      You may have to get opinions from multiple veterinarians as some specialize in holistic, some conventional, etc.; however, here is a list of vets who may be able to help. You can search by state to find the one nearest to you. We wish you luck in finding the best regimen for Mimi.

  19. Amy says:

    Hi. My dog was recently diagnosed with Cushings. We started Vetryol yesterday. Is it safe to use that and the holistic meds at same time? If we switch to holistic, how long till we should see the excessive drinking and peeing diminish? Also, what can help him sleep at night.? He is so focused on finding water that he isn’t sleeping. Thank you!

    • Cushings in Dogs says:

      Sometimes it is recommended to utilize both medical and holistic treatment options at the same time. This regimen is safe; however, it is important to always consult your vet first as they know your dog’s Cushings case best and your dog could have other complicating factors. As for the symptoms, every dog is different. If you choose supplements like lignans and melatonin, studies have shown them to be effective in about 85% of cases. If you see an improvement, you might only see one or two symptoms improve. Some dog owners who found success saw improvement in all symptoms. On average, symptoms improve in two months but it can take up to four. Lignans and melatonin can reduce the heightened cortisol levels in Cushingoid dogs, which can help manage the increased appetite, excessive drinking, anxiety/pacing, etc. We hope this helps, and don’t forget to discuss all of your options with your vet. We wish you luck in finding the best possible treatment regimen for your dog.

  20. Ashley says:

    My Yorkie was diagnosed 2 years ago with chronic encephalitis and must take 2.5 mg of prednisone every other day. He was recently diagnosed with diabetes then Cushings. Since he has to continue the prednisone, will these natural products work for him at all? Thank you!

    • Cushings in Dogs says:

      One of the causes of Cushings is the administration of too many steroids, so the solution to manage the Cushings would be to reduce the steroids. However, since your dog has multiple diagnoses, it is important to discuss all options with your vet. Some natural products like lignans and melatonin could counteract the effects of the prednisone, but the better solution might be to reduce the prednisone, if possible. We recommend sharing this information with your vet and discussing natural options with them as they are most familiar with your dog’s case and your dog appears to have complicating factors. We wish you luck in finding the best regimen.

  21. Adam Wall says:

    The hyperadrenocorticism or Cushing’s disease is an endocrine irregularity that normally occurs when the adrenal glands of the dog produce cortisol hormone in a superabundant fashion. The excessive production of cortisol hormone weakens too many body organs of your furry friend and prevents them from functioning well. Thus, spotting the syndromes at the right time is crucial for your canine companion’s longer life-expectancy. But as it is difficult for a pet owner to identify the symptoms in the first place, so he should take the help of a vet after noticing any sort of irregular behavior to ensure that his four-legged furry companion can live a long life without any discomfort.

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